Vacancy No. IPE 02-17

IPE 02-17 \ Thesis or Internship: Multimodal breast image registration

Job description


At Karlsruhe Institute of Technology an automated method for multimodal image registration of 2D Xray

mammograms, Tomosynthesis, 3D breast MRI and 3D Ultrasound Computer Tomography volumes is developed. The registration allows localizing suspicious tissue structures in all modalities at a glance. Using this approach the advantages of modalities may be combined. Our method therefore contributes to computer aided multimodal diagnosis of breast cancer. The challenge of the image registration is the considerable

difference between the images of the modalities: while X-ray mammograms and Tomosynthesis volumes are acquired during compression of the breast between two plates, MRI images the breast in 3D without applying compression. USCT images breast under buoyancy conditions while in breast MRI the breast is imaged subject to gravity in prone position. Our registration method is based on simulating the deformation of the breast during the different imaging processes using a patient-specific biomechanical model.



The aim of this work is to develop an automated workflow for registering all modalities by integrating the data preprocessing, the biomechanical model, the deformation simulation as well as the postprocessing. The current methods (e.g. image segmentation) should be analyzed in terms of robustness and extended if necessary. Methods for visualization of the results and evaluation of the accuracy should be included in the workflow. Furthermore an image-based optimization of the registration parameters is intended to adapt the registration to each individual patient and determine the best registration accuracy. For this a speedup of the applied algorithms might be necessary, e.g. by using GPU accelerated libraries. The effect of the extended biomechanical model and the optimization of parameters will be evaluated with clinical datasets, which will

be provided.


Task description (topics will be adapted to available time frame)

  •  Starting point of the work will be the analysis of the current state of the registration method
  •  Afterwards a concept for an automated workflow should be developed.
  •  Implementation of the workflow based on the existing software and integration of  
         existing functionality as well as development of new image processing methods extending
         the current state.


Personal qualification
  •  Programming skills in MATLAB required.
  •  Interest in medical imaging and medical image processing, in particular image segmentation
  •      and image Registration.
  •  Basic knowledge in (bio-)mechanical simulations / Finite Element simulations beneficial.
Organizational unit

Institute for Data Processing and Electronics (IPE)

Starting date

On appointment

Contact person

Torsten Hopp,


Please apply by clicking on "Apply" below.

If qualified, handicapped applicants will be preferred.